Release date: 2017-04-06 If someone tells you that he doesn't need to know what kind of genetic mutation is caused by the patient's cancer, just add an invisible, inexplicable "electric field" to the patient, which can effectively kill cancer cells, and the side effects are smaller than chemotherapy. Do you believe it? Many people may think that he is a liar. When it comes to cancer treatment, most of the words that come to mind are surgery, radiotherapy, and chemotherapy. Friends who care about the progress of the pharmaceutical industry may have heard of targeted therapies, immunotherapies and cell therapies, which are at the forefront of cancer prevention. Treating cancer with an "electric field"? This sounds too much like a fake advertisement. ▲ At this year's annual meeting of the American Association for Cancer Research, many experts witnessed the progress of this “false therapy†(Source: AACR) On Sunday, at the annual meeting of the American Association for Cancer Research, one of the largest cancer conferences in the United States, this anti-cancer approach that sounded "false" made many of the experts here stunned - it In the combination therapy of glioblastoma (malignant brain tumor), the effect far exceeds the single treatment of chemotherapy. In addition, it has achieved good results in the treatment of ovarian cancer and even the "king of cancer" pancreatic cancer. “These results are so good that there is nothing to say,†said Antonio Chiocca, chief neurosurgeon at Brigham and Women's Hospital in Boston, after seeing the data. The technology that makes first-class experts feel incredible, the full name is "tumor treating fields", and its inventor is Professor Yoram Palti of the Israel Institute of Technology. We need to make a distinction between this technology: first, it is not the current flowing through the human body; secondly, it is not ionizing radiation like X-ray or radiotherapy; third, the electric field is not magnetic. What is the electric field? We can take the magnetic field to make an analogy. A magnetic field is generated around the magnet, which can affect the surrounding magnetic material. The electric field is similar, as a force field, it can affect the surrounding charged material. What does this have to do with cancer treatment? We know that cancer cells are a group of cells that divide rapidly, and in the process of dividing these cells, a special type of tubulin is needed. In cell division, they form a "rope" that connects genetic material and pulls them from one cell to two. If there is a problem with the link between these proteins, the cell division will also be problematic, which often leads to cell death. Interestingly, these proteins carry a lot of charge. Therefore, if we apply a certain electric field, we may be able to disrupt the function of these proteins in rapidly dividing cancer cells and play an anti-cancer role. ▲The electric field can produce anti-cancer effects by inhibiting cell division (Source: Novocure official website) The researchers quickly verified their ideas in a Petri dish. After experimenting with 20 different cancer cells, they found that this electric field can inhibit all cancer cells. More importantly, these tumor treatments have little effect on normal cells that divide slowly! ▲The electric field has no interference effect on normal cells with slower division (Source: TED) Next, the researchers began to study the effects of the electric field in the patient. First, they targeted the glioblastoma. This is a malignant brain tumor that is less than 5% of patients who have survived for 5 years after diagnosis. Because it is sick in the brain, and other nerve cells in the brain are not actively dividing, the researchers predict that this cancer can well reflect the effect of tumor treatment of electric fields. So they recruited a group of patients with glioblastoma. They have all been treated with surgery, radiotherapy and chemotherapy, but the tumor still relapses and life is at stake. The researchers divided the patients into two groups, one receiving second-line chemotherapy and the second receiving tumor-treated electric fields. The trial yielded two interesting results—first, the life expectancy of patients receiving chemotherapy and electric field treatment was similar, and higher than those without treatment; second, patients receiving electric field treatment did not suffer from any side effects of chemotherapy. ▲ Some patients put on the “electric field cap†and can work while treating (Source: medicalxpress) Despite the gratifying results, the researchers did not stop moving forward. If both chemotherapy and electric field treatment have similar effects, what happens when the two are combined? To test the combined effects of the two therapies, the researchers launched a large phase 3 clinical trial that recruited nearly 700 patients and continued to observe 40 months for more than half of them. The patience of the researchers came to the harvest - compared with patients who used the chemotherapy drug temozolomide alone, the 2-year survival rate increased from 30% to 43% in patients who used temozolomide and electric field therapy. . The five-year survival rate comparison is even more amazing. The 5-year survival rate of patients in the chemotherapy group was 5%, while patients who also used electric field therapy had a 5-year survival rate of 13%! In other words, the use of electric field therapy in addition to chemotherapy can more than double the survival rate of patients. “I have been treating glioblastoma for more than 20 years. Most of my patients have died in a year. The long-term survival case is almost zero,†said Robert H. Lurie Comprehensive Cancer. Dr. Roger Stupp, deputy director of the Center of Northwestern University, said: "Now, we have seen meaningful progress, patients can live for more than 2 years. Under the combined treatment, one out of seven patients can survive. 5 years!" ▲The patient's survival treatment has been greatly improved with the help of electric field therapy (Source: Novocure official website) This is not the whole story. There may be different reasons behind different cancers, but these tumors all share a common feature - rapid division. If this electric field therapy is effective for glioblastoma, it is likely to be effective for other tumors as well. This is true. In a Phase 2 clinical trial, the combination of electric field and paclitaxel increased the median progression-free survival of patients with recurrent ovarian cancer from 3.9 months (chemotherapy with paclitaxel alone) to 8.9 months (combination therapy). More than doubled; in another phase 2 clinical trial, it increased the progression-free survival of patients with advanced pancreatic cancer from 5.5 months (chemotherapy with paclitaxel and gemcitabine only) to 12.7 months. More than doubled. The researchers plan to present the results of the two trials at the annual meeting of the American Cancer Research Association on April 4, local time. As some chief physicians of brain tumors say, this electric field therapy is undoubtedly a major advance. We expect it to validate the efficacy in more cancers and bring more treatment options to patients. Reference material [1] A 'sci-fi' cancer therapy fights brain tumors, study finds [2] Combination of Tumor Treating Fields with Standard of Care Therapies, Nab-Paclitaxel and Gemcitabine, Suggests Improved Survival of Patients with Advanced Pancreatic Cancer [3] Combination of Tumor Treating Fields with Paclitaxel may Improve Survival of Patients with Recurrent Ovarian Cancer [4] Combination of Optune? with Standard of Care Chemotherapy, Temozolomide, Provides Landmark Five-Year Survival Rates for Newly Diagnosed Glioblastoma Patients Source: Health New Vision (Micro Signal HealthHorizon) Active Pharmaceutical Ingredient medicinal extract,Pure loofah powder,blackberry juice powder Fufeng Sinuote Biotechnology Co.,Ltd. , https://www.sntbiology.com